Toshinari Takamura Selected Research

Insulin (Novolin)

8/2022	Forkhead box protein O1 (FoxO1) knockdown accelerates the eicosapentaenoic acid (EPA)-mediated Selenop downregulation independently of sterol regulatory element-binding protein-1c (SREBP-1c) in H4IIEC3 hepatocytes.
5/2021	Moderate alcohol consumption is associated with impaired insulin secretion and fasting glucose in non-obese non-diabetic men.
2/2020	Study Protocol for Pleiotropic Effects and Safety of Sodium-Glucose Cotransporter 2 Inhibitor Versus Sulfonylurea in Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Disease.
1/2020	Hepatokine Selenoprotein P-Mediated Reductive Stress Causes Resistance to Intracellular Signal Transduction.
1/2019	p62-mediated autophagy affects nutrition-dependent insulin receptor substrate 1 dynamics in 3T3-L1 preadipocytes.
11/2018	Serum selenoprotein P, but not selenium, predicts future hyperglycemia in a general Japanese population.
10/2018	Heterogeneous nature of diabetes in a family with a gain-of-function mutation in the ATP-binding cassette subfamily C member 8 (ABCC8) gene.
7/2017	Weight-adjusted lean body mass and calf circumference are protective against obesity-associated insulin resistance and metabolic abnormalities.
1/2017	Eicosapentaenoic acid down-regulates expression of the selenoprotein P gene by inhibiting SREBP-1c protein independently of the AMP-activated protein kinase pathway in H4IIEC3 hepatocytes.
11/2015	Bending of a vertical cannula without alarm during insulin pump therapy as a cause of unexpected hyperglycemia: A Japanese issue?

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Toshinari Takamura Research Topics

Disease

52	Insulin Resistance 03/2022 - 02/2003
37	Type 2 Diabetes Mellitus (MODY) 08/2022 - 06/2005
20	Non-alcoholic Fatty Liver Disease 08/2021 - 01/2007
15	Obesity 01/2022 - 12/2005
9	Fibrosis (Cirrhosis) 08/2021 - 01/2007
9	Fatty Liver 08/2021 - 01/2007
8	Hyperglycemia 06/2022 - 04/2007
8	Inflammation (Inflammations) 12/2021 - 11/2007
7	Neoplasms (Cancer) 05/2022 - 01/2005
7	Glucose Intolerance 05/2021 - 01/2007
7	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2009 - 06/2003
6	Liver Cirrhosis (Hepatic Cirrhosis) 08/2021 - 11/2006
6	Alcoholic Fatty Liver 10/2019 - 09/2005
5	Albuminuria 11/2020 - 04/2002
5	Diabetic Nephropathies (Diabetic Nephropathy) 05/2015 - 04/2002
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2021 - 10/2019
4	Body Weight (Weight, Body) 01/2020 - 01/2012
4	Atherosclerosis 04/2017 - 12/2003
3	Osteoporosis 01/2022 - 01/2007
3	Heart Failure 01/2021 - 06/2005
3	Neoplasm Metastasis (Metastasis) 01/2012 - 01/2008
2	Cushing Syndrome 05/2022 - 01/2010
2	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2022 - 09/2021
2	Hepatitis 08/2021 - 09/2005
2	Diabetes Mellitus 11/2020 - 10/2018
2	Weight Loss (Weight Reduction) 01/2020 - 02/2010
2	Weight Cycling 01/2020 - 01/2016
2	Disease Progression 07/2019 - 06/2017
2	Overweight 05/2019 - 05/2018
2	Starvation 01/2019 - 05/2014
2	Myocardial Infarction 03/2018 - 02/2010
2	Myocardial Ischemia (Ischemic Heart Diseases) 03/2018 - 02/2010
2	Hepatocellular Carcinoma (Hepatoma) 03/2017 - 03/2013
2	Overnutrition 01/2016 - 01/2012
2	Proteinuria 05/2015 - 11/2013
2	Chronic Hepatitis C 10/2012 - 09/2005
2	Biliary Liver Cirrhosis (Primary Biliary Cirrhosis) 01/2012 - 09/2005

Drug/Important Bio-Agent (IBA)

33	Glucose (Dextrose)FDA LinkGeneric 03/2022 - 01/2007
26	Insulin (Novolin)FDA Link 08/2022 - 02/2003
18	Selenoprotein PIBA 08/2022 - 11/2010
13	Proteins (Proteins, Gene)FDA Link 01/2020 - 11/2010
8	Fatty Acids (Saturated Fatty Acids)IBA 03/2017 - 11/2007
7	Messenger RNA (mRNA)IBA 12/2021 - 03/2009
7	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 07/2008
6	Chemotactic FactorsIBA 12/2021 - 05/2014
6	Triglycerides (Triacylglycerol)IBA 07/2017 - 01/2007
6	LipidsIBA 01/2012 - 06/2004
5	AlbuminsIBA 08/2021 - 10/2012
5	Biomarkers (Surrogate Marker)IBA 08/2021 - 10/2012
5	empagliflozinIBA 01/2021 - 04/2017
5	EnzymesIBA 01/2021 - 02/2003
5	Pioglitazone (Actos)FDA Link 12/2010 - 06/2005
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 07/2008 - 12/2003
4	Metformin (Glucophage)FDA LinkGeneric 01/2021 - 01/2012
4	Short-Acting InsulinIBA 01/2018 - 03/2007
4	Sitagliptin Phosphate (Januvia)FDA Link 01/2018 - 01/2015
4	Plasminogen Activator Inhibitor 1IBA 03/2013 - 12/2003
3	Somatostatin Receptors (Somatostatin Receptor)IBA 05/2022 - 01/2012
3	SeleniumIBA 01/2021 - 11/2018
3	Glucagon (Glukagon)FDA Link 02/2020 - 03/2007
3	Arginine (L-Arginine)FDA Link 07/2019 - 03/2007
3	AdiponectinIBA 01/2012 - 11/2007
3	DNA (Deoxyribonucleic Acid)IBA 11/2010 - 02/2003
2	Adrenocorticotropic Hormone (ACTH)FDA Link 05/2022 - 01/2005
2	IsotopesIBA 03/2022 - 07/2019
2	CytokinesIBA 01/2022 - 12/2003
2	Intrinsic Factor FDA Link 01/2022 - 01/2020
2	Phosphates (Orthophosphate)IBA 01/2022 - 09/2021
2	CarbohydratesIBA 10/2021 - 05/2016
2	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 10/2021 - 01/2014
2	Antiviral Agents (Antivirals)IBA 08/2021 - 04/2019
2	Sodium-Glucose Transport ProteinsIBA 01/2021 - 04/2017
2	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2021 - 04/2017
2	SodiumIBA 01/2021 - 02/2020
2	CreatinineIBA 11/2020 - 05/2015
2	fibroblast growth factor 21IBA 01/2020 - 05/2018
2	AntioxidantsIBA 01/2020 - 11/2007
2	palmitoleic acidIBA 10/2019 - 02/2015
2	Insulin-Like Growth Factor I (IGF-1)IBA 10/2018 - 01/2012
2	somatostatin receptor 2IBA 10/2018 - 01/2012
2	Octreotide (Sandostatin)FDA LinkGeneric 10/2018 - 01/2012
2	Phosphotransferases (Kinase)IBA 03/2018 - 03/2013
2	A-Form DNA (A-DNA)IBA 01/2018 - 12/2008
2	Insulin Aspart (NovoLog)FDA Link 01/2018 - 06/2012
2	Alanine Transaminase (SGPT)IBA 07/2017 - 09/2005
2	Branched-Chain Amino AcidsIBA 03/2017 - 10/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 09/2014
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2016 - 03/2007
2	Hemoglobins (Hemoglobin)IBA 01/2016 - 11/2013
2	Pravastatin (Pravachol)FDA LinkGeneric 05/2015 - 09/2008
2	Atorvastatin (Lipitor)FDA Link 05/2015 - 09/2008
2	CholesterolIBA 05/2014 - 11/2007
2	Raloxifene Hydrochloride (Evista)FDA Link 03/2013 - 01/2007
2	Hyaluronic Acid (Hyaluronan)IBA 01/2012 - 01/2007
2	Pharmaceutical PreparationsIBA 12/2010 - 07/2008
2	Pancreatic Elastase (Elastase)IBA 01/2009 - 03/2006
2	Methionine (L-Methionine)FDA Link 07/2008 - 01/2007

Therapy/Procedure

17	Therapeutics 08/2021 - 03/2006
6	Glycemic Control 11/2019 - 02/2010
2	Diet Therapy (Therapy, Diet) 01/2016 - 05/2015